Transformed African Green Monkey Kidney Fibroblast Cells (COS-1 Line)

The transformed COS-1 cell line was derived from the CV-1 fibroblast line, which was initiated in March, 1964 by F. C. Jensen and colleagues from the normal kidney of an adult African green monkey. Developed by Yakov Gluzman, the COS-1 cell line differs from CV-1 due to transformation of the earlier line with an origin defective mutant of simian virus 40 (SV40) that codes for wild type T-antigen.